Roche Cobas C 111
Roche · Model Cobas C 111
Automated sample and reagent pipeting allows operators to walk away for 45-60 minutes Connectivity options for testing and data management Up to 65 photometric tests/hour and 180 electrolyte tests/hour (85-100 tests/hr combined) Onboard capacity for up to 17 tests at a time (3 ISEs & 14 photometric tests) Intuitive user interface simplifies use for different skill and access levels Continuous loading and unloading of virtually any sample tube or cup Cooled, exchangeable reagent disks make loading flexible and efficient Software-driven operation for minimal maintenance and maximum uptime Currently more than 30 assays, with more planned for release in the near future Covers the basic and comprehensive metabolic panels, electrolyte and lipid panels, hepatic and renal function panels. Includes innovative tests such as whole blood HbA1.
Key tips
- ·Run QC controls before trusting any repair - an analyzer that passes self-test can still report clinically wrong results.
- ·Rule out a reagent lot change before opening the instrument - it can look exactly like a hardware fault.
- ·Centrifuge rotors have a hard retirement age/cycle limit regardless of visible condition - don't eyeball it.
Typical Failure Modes
Compiled for this model from its own documentation and established engineering knowledge for this equipment class - not from a verified service record. Confirm against the manufacturer's service manual.
Assay / QC failure across a channel or the whole system
HighSymptoms: Controls out of range, calibration fails, flagged results, drift over a shift.
Root cause: Reagent or cuvette issue, lamp ageing, a probe / mixer / wash-station fault, or ISE-module problems.
Sample / reagent probe clog or crash
MediumSymptoms: Short aspiration, no dispense, clot detection, probe-position error.
Root cause: Clogged or bent probe, or a clot in the sample.
Cuvette / reaction-rotor fault
MediumSymptoms: High cuvette blanks, non-uniform results by position, rotor-drive error.
Root cause: Worn / scratched cuvettes or a wash fault, or a rotor-drive fault.
ISE module fault (Na / K / Cl)
MediumSymptoms: Electrolyte results biased or noisy, ISE calibration fails.
Root cause: Aged ISE electrodes / reference, or a pinch-valve / tubing fault.
Water / vacuum / pressure system fault
MediumSymptoms: Multiple station alarms, priming failures, poor wash.
Root cause: Water / DI supply quality, a pump, or a vacuum / pressure regulator.
Serviceable Parts & Consumables
Serviceable items for this model, compiled from its documentation and engineering knowledge for this equipment class. Service class and relative cost are estimates, not manufacturer figures; no part numbers are given. Confirm intervals and pricing against the manufacturer.
Sample / reagent probes
Class Periodic replacementRel. cost $$R&R Moderate
Photometer lamp
Class Frequent wear itemRel. cost $$R&R Moderate
Reaction cuvettes / segment
Class Frequent wear itemRel. cost $$R&R Easy
ISE electrodes (Na / K / Cl) & reference
Class Frequent wear itemRel. cost $$R&R Fairly easy
Peristaltic / pinch-valve tubing
Class Frequent wear itemRel. cost $R&R Moderate
| Part | Service class | Relative cost | R&R difficulty |
|---|---|---|---|
| Sample / reagent probes | Periodic replacement | $$ | Moderate |
| Photometer lamp | Frequent wear item | $$ | Moderate |
| Reaction cuvettes / segment | Frequent wear item | $$ | Easy |
| ISE electrodes (Na / K / Cl) & reference | Frequent wear item | $$ | Fairly easy |
| Peristaltic / pinch-valve tubing | Frequent wear item | $ | Moderate |
Relative cost: $ lowest · $$$$ highest service-part cost for this equipment class. Not a price.
PM Checklist
Preventive-maintenance tasks typical of this equipment class. Perform to the manufacturer's procedure and your facility's policy - this is general reference, not a schedule for this specific unit.
- ·Daily QC controls run and reviewed
- ·Calibration verification per assay
- ·Routine cleaning and decontamination
- ·Scheduled reagent-path and pump-tubing maintenance
Troubleshooting Approach
A starting sequence for this model, compiled from its documentation and engineering knowledge for this equipment class. Follow the manufacturer's service documentation for the actual procedure.
Symptom: Assay or QC failure
- Run fresh controls at all levels.
- Confirm reagents are in date, correctly loaded and mixed.
- Run the photometer check and replace the lamp if energy is low.
- Clean the probes, mixers and wash stations.
- Recalibrate the affected assay / ISE module and re-run QC.
Symptom: Probe clog or crash
- Inspect the probe for a bend or blockage and clear it.
- Run the fluidics prime / wash cycle.
- Check for a clot in the sample.
- Verify liquid-level sensing and probe positioning.
- Replace the probe if aspiration is still short.
Technical Specs
- Height
- 480 mm
- Throughput
- 60 - 80 tests/hr
- Length
- 550 mm
- Weight
- 32.3 kg
- Width
- 590 mm
Typical Location
Where this class of equipment is typically deployed - general reference, not this unit's own placement record.
- Central / core laboratory
- Point-of-care testing stations
- Blood bank
- Microbiology lab
Documents & Manuals
- Cobas C 111 Reference GuideUser Manual · External
- Cobas C 111 User ManualUser Manual · External
- Cobas C 111 BrochureBrochure · External
- Cobas C 111 Press ReleaseDocument · External
- Cobas C 111 SpecificationsDocument · External
- Cobas C 111 Test MenuDocument · External
- Roche Cobas C111 Installation Manual.pdfDocument · External
- Installation Manual.pdfDocument · External
Safety & Recalls
Synced live from the FDA openFDA API.
- RECALL
Internal investigations have revealed a potential printer malfunction on the Cobas c 111 analyzer, where one or more numbers or characters can be missing on the hard copy result printout, or the printer may skip leaving blanks which may result in an incorrect print layout. The missing number of characters can be in any position, therefore it could be in the middle of a result, (e.g. 48.53 mmol in
- RECALL
Due to a manufacturing error at the supplier, not all cobas c 111 pinch valve caps are properly glued to the correct position on the pinch valve shaft. Without the glue, the cap can become loose or misaligned. The effect of these faulty valves is that they may not open or close properly which can disturb the fluid transportation within the ISE module resulting in problems with ISE calibration, con
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