TransMedics Organ Care System (OCS) Lung System

TransMedics · Model Organ Care System (OCS) Lung System

How does it work? The OCS Lung System works by supplying donor lungs with oxygen and nutrients through ventilation and perfusion. The device also measures and displays preservation parameters, such as temperature and pressure. When is it used? The TransMedics OCS Lung System is used by trained medical personnel during the retrieval and transportation of donor lungs. What will it accomplish? Compared to the standard of care cold storage method for preservation of donor lungs, the OCS System reduces the time during which the lungs lack blood and oxygen support outside of the body. In a clinical study that compared the OCS System to cold storage, a lower rate of Primary Graft Dysfunction Grade 3 (PGD3) within 72 hours post-transplantation was observed in patients transplanted with lungs preserved by the OCS System. PGD3 is a severe form of acute lung injury that is associated with poor clinical outcomes. Other clinical outcomes, such as survival and rate of bronchiolitis obliterans syndrome (BOS) at two years post-transplantation, were similar between the two study groups. BOS is a common long-term complication after lung transplantation. When should it not be used? The TransMedics OCS Lung System cannot be used with donor lungs that have suffered moderate to severe traumatic injury with air leak, as seen on radiological studies, bronchial examination or final visual assessment in donor’s chest.